Liverpool are scheduled to take on Villa in the third round of the competition this evening at 19:45 GMT.
The fixture was plunged into doubt yesterday evening when a large number of COVID-19 cases emerged from the Villa first-team squad.
Villa’s training ground at Bodymoor Heath was forced to shut down, as a result.
With Dean Smith and his first-team squad all in isolation, Villa U23s coach Mark Delaney is expected to oversee proceedings at Villa Park, as per The ECHO.
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Liverpool were forced into similar circumstances last season, after all.
Klopp was forced to field a team of academy stars in a Carabao Cup quarter-final clash against Aston Villa, while the first team were in Qatar for the FIFA Club World Cup back in December 2019.
Jurgen Klopp and his team will travel as normal ahead of the Friday night clash in the Midlands.
Alisson to start?
The Liverpool boss is expected to make wholesale changes to the team that was beaten by Southampton earlier this week.
However, it seems Klopp could be expected to keep a selection of key personnel in his starting XI, including goalkeeper Alisson [£66.8 million].
The 29-year-old hinted at such with a photo on his Instagram page.