Naby Keita suffered a suspected groin injury against Barcelona on Wednesday evening and had to be substituted in the first half, according to Goal.
The Guinean suffered the injury after a crunching challenge from Ivan Rakitic and, although he played on for another few minutes, he eventually pulled up and was withdrawn.
Jordan Henderson entered the fray in his place but the 24-year-old was a big miss as Liverpool lost their penetration from central areas and allowed the home side to gain a foothold in the game.
It is a cruel break for Keita as he has been in fine form since being reinstated into the starting XI over the last four weeks.
His silky dribbling and high pressing have been crucial to Liverpool picking up maximum points against Southampton, Chelsea, Cardiff and most recently Huddersfield.
If his groin injury is serious, it will be a blow to both Liverpool’s Champions League hopes and their bid to win the Premier League which will more likely than not require Klopp’s side to win its remaining three games.
Liverpool will need to prepare for the second leg at Anfield next week with the knowledge that they will need to score at least four goals with no reply in regular time to progress.
While it’s more than likely game over for the Reds, it would fly in the face of everything this club stands for to rule out another dramatic European night under the lights.